Endocrine Abstracts

Context: Diabetes mellitus represents one of the most frequent metabolic comorbidities and occurs in 30% to 40% of patients with acromegaly. Patients with acromegaly develop insulin resistance due to GH excess, and in those with longstanding disease, insulin deficiency may occur. Moreover, the use of second-generation somatostatin receptor ligands (SRLs) pasireotide might contribute to the increased development in new-onset diabetes and the worsening of hyperglycemia. Manageme...

Introduction: Acromegaly is a chronic disease generally caused by a GH-secreting pituitary adenoma. GH excess causes insulin resistance and impair β cell function, predisposing patients with acromegaly to develop DM. Treatment of diabetes has been revolutionized since the introduction of sodium-glucose cotransporter inhibitors (SGLT2i). This novel class is widely used in type 2 diabetes mellitus (T2DM) and recently was approved for patients with heart failure with reduced...